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[Trans-translation: facts and hypothesis]

O V Shpanchenko, E Iu Bugaeva, A V Golovin

    Molekuliarnaia Biologiia
    |September 29, 2010
    PubMed

    Insights

    Trans-translation rescues stalled bacterial ribosomes from nonstop messenger RNAs (tmRNAs) and targets them for degradation. This essential process ensures bacterial survival and regulates cellular pathways.

    Area of Science:

    • Molecular Biology
    • Bacterial Physiology

    Context:

    • Trans-translation is a crucial bacterial process.
    • It rescues stalled ribosomes translating nonstop messenger RNAs (mRNAs).
    • It directs arrested mRNAs and nascent polypeptides for degradation.

    Purpose:

    • To review recent advances in trans-translation research.
    • To elucidate the tmRNA-SmpB interaction and ribosomal complex structures.
    • To discuss ribosome stalling, recognition, and resume codon determination.

    Summary:

    • This review details the tmRNA-SmpB interaction and early ribosomal complex structures.
    • It explores the causes of empty A site, stalled ribosome recognition, and resume codon determination.
    • The proteins involved in nonstop mRNA and tagged peptide degradation are also examined.

    Impact:

    • Understanding trans-translation is vital for bacterial survival.
    • It plays a key role in translation quality control.
    • It influences the regulation of bacterial physiological pathways.

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