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Updated: Jun 8, 2026

Assessment of The Effect of Antidiarrheal Drugs and Plant Extracts on Drosophila melanogaster
Published on: November 17, 2023
[Screening of anti-diarrhea effective fractions from guava leaf]
Wen-biao Lu1, Bei-en Zhang, Jing Wang
1Guangzhou University of Chinese Medicine, Guangzhou 510405, China. vip.luwbl@gzhtcm.edu.cn
Objective:
To screen the fractions from guava leaf to ascertain the effective anti-diarrhea fraction and to establish the method of quality control.
Methods:
A series of samples from guava leaf were prepared through extraction and separation by solvents progressively, and their effect on the mice diarrhea models induced by senna decoction were tested individually; and the constituent correlated with the effect of the samples on the models was determined by HPLC.
Results:
The effect of the fractions with moderate-polar glucosides from guava leaf was better than that of the other fractions; the effect of the fractions with the glucosides was correlated with the content of the quercetin glucosides in the fractions.
Conclusion:
The fractions with the moderate-polar glucosides is the effective anti-diarrhea fraction of guava leaf; determination of the quercetin glucosides can be used for quality control of guava leaf and its extracts.
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