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Updated: Jun 8, 2026
Primary Outcome Assessment in a Pig Model of Acute Myocardial Infarction
Published on: October 14, 2016
[Effects of ginkgolide on hemodynamics in myocardial ischemic dogs]
Yan-yan Yin1, Xiao-fen Min, Wei-zu Li
1Department of Pharmacology, Anhui Medical University, Hefei 230032, China. yinyanyan5678@126.com
Objective:
To investigate the effects of Ginkgolide on hemodynamics and myocardial oxygen metabolism in acute myocardial ischemic dogs.
Methods:
Acute myocardial ischemic model dogs were established by ligating left anterior descending coronary artery (LAD). Some hemodynamic parameters and cardiac oxygen consumption were observed after Ginkgolide were given to dogs through the duodenum.
Results:
Ginkgolide could increase LVSP, + dp/dt(max), LVWI, SW, CO and CBF, decrease TPVR, CVR, MVO2 and MOUR of Acute myocardial ischemic model dogs at different time points after ligation of LAD.
Conclusion:
Ginkgolide can improve the hemodynamic conditions and oxygen metabolism of myocardial ischemic dogs.
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