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Updated: Jun 8, 2026
Preparation and Characterization of Individual and Multi-drug Loaded Physically Entrapped Polymeric Micelles
Published on: August 28, 2015
[Preparation and characterization of curcumin polybutylcyanoacrylate nanoparticles]
Xiu-qing Zhu1, Min Sun, Fan-ping Zhu
1College of Pharmacy, Shandong University, Jinan 250012, China.
Objective:
To prepare curcumin polybutylcyanoacrylate nanoparticles (Cur-PBCNs) and evaluate its characteristics.
Methods:
Cur-PBCNs were prepared by emulsion polymerization, and the formulation was optimized by L16 (4(3)) orthogonal design test with entrapment efficiency and drug loading as indices. In addition, its characteristics were investigated.
Results:
The nanoparticles were spherical in appearance under transmission electron microscope (TEM). The mean diameter of the nanoparticles was 93.8 nm, the mean entrapment efficiency was (50.4 +/- 2.2)%, the mean drug-loading was (33.5 +/- 0.9)% and the Zeta potential was -6.81 mV. The total drug release was 34.74% in 2 hours followed by a sustained release in vitro for Cur-PBCNs, and the in vitro release profile of the nanoparticles was fit for two phases kinetics equation: 100 - Q = 4.5235e(-0.1724t) + 4.1641e(-0.0114t).
Conclusion:
The optimal Cur-PBCNs show good characteristics and sustained release character in vitro.
