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Published on: May 12, 2023
[Optimization of molding technics of xiaochuang granules by central composite design-response surface methodology]
Wei-wei Chen1, Yu-mei Nong, Dan Liang
1Guangxi Traditional Chinese Medical University, Nanning 530001, China. weiwei690413@eyou.com
Objective:
The optimal molding technics of Xiaochuang granules was selected.
Methods:
The main influential factors of the molding technics included the mixed excipients' ratio, the quantity times of excipients and the ethanol concentration. The molding effect was evaluated with the yield of qualified granules and solubility. The optimal technics of Xiaochuang granules was selected by central composite design-response surface methodology.
Results:
The optimal molding technics were as follows: the quantity times of excipients was 2.0, the proportion between mixed excipents (dextrin: lactose) was 1:1, and the ethanol concentration was 65%.
Conclusion:
The molding technics of Xiaochuang granules is reasonable, stable and reliable.
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01:28Methods of Medium Optimization
01:16Response Surface Methodology
The process of RSM involves several key steps: