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Sharing unexpected biomarker results with study participants
Ann D Hernick1, M Kathryn Brown, Susan M Pinney
1Breast Cancer Alliance of Greater Cincinnati, Cincinnati, Ohio, USA. adhernick@yahoo.com
Environmental Health Perspectives
|September 30, 2010
Summary
Elevated perfluorooctanoate (PFOA) levels were found in young girls in a community study. Researchers developed a communication plan to share these unexpected environmental exposure findings with families.
Area of Science:
- Environmental Health
- Biomarker Research
- Puberty Timing Studies
Background:
- Breast Cancer and the Environment Research Centers (BCERCs) investigate environmental exposures and puberty timing.
- A pilot study assessed biomarker feasibility in young girls (6-8 years).
- Elevated perfluorooctanoate (PFOA) serum concentrations were detected in over 90% of girls in a specific community.
Purpose of the Study:
- To deliberate on the ethical considerations and methods for reporting unexpected PFOA findings to study participants.
- To outline the decision-making process and communication strategies for sharing environmental biomarker results.
Main Methods:
- Verification of PFOA results and investigation into potential exposure sources.
- Research team discussion on reporting unexpected findings with unknown clinical significance.
- Development and implementation of a communication plan to present findings to study families.
Main Results:
- High prevalence of elevated PFOA serum concentrations (>90%) identified in young girls.
- Unexpected environmental exposure findings necessitated careful consideration for reporting.
- A structured communication plan was utilized to disclose the PFOA results.
Conclusions:
- Ethical debates arose concerning the precautionary principle, right to know, and do no harm.
- Transdisciplinary research models and biomarker advancements necessitate robust participant communication plans.
- Effective communication strategies are crucial for studies involving environmental exposures and participant well-being.
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