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Related Concept Videos

Circadian Rhythms and Gene Regulation02:19

Circadian Rhythms and Gene Regulation

The biological clock is involved in many aspects of regulating complex physiology in all animals. It was in 1935 when German zoologists, Hans Kalmus and Erwin Bünning, discovered the existence of circadian rhythm in Drosophila melanogaster. However, the internal molecular mechanisms behind the circadian clock remained a mystery until 1984, when Jeffrey C. Hall, Michael Rosbash, and Michael W. Young discovered the expression of the Per gene oscillating over a 24-hour cycle. In subsequent years,...
Circadian Rhythms and Gene Regulation02:19

Circadian Rhythms and Gene Regulation

The biological clock is involved in many aspects of regulating complex physiology in all animals. It was in 1935 when German zoologists, Hans Kalmus and Erwin Bünning, discovered the existence of circadian rhythm in Drosophila melanogaster. However, the internal molecular mechanisms behind the circadian clock remained a mystery until 1984, when Jeffrey C. Hall, Michael Rosbash, and Michael W. Young discovered the expression of the Per gene oscillating over a 24-hour cycle. In subsequent years,...
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Scaled modeling is a fundamental technique in engineering, enabling the study of large and complex systems by creating smaller, manageable replicas that recreate critical characteristics of the original. In hydrology and civil infrastructure, for example, scaled models of dams help analyze water flow, turbulence, and pressure. This method allows for accurate predictions of real-world behavior within a controlled environment, significantly reducing the cost and time involved in full-scale...
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Parametric Surfaces

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Collecting Sleep, Circadian, Fatigue, and Performance Data in Complex Operational Environments
08:36

Collecting Sleep, Circadian, Fatigue, and Performance Data in Complex Operational Environments

Published on: August 8, 2019

Modeling a circadian surface.

Till Roenneberg1, Jan Rémi, Martha Merrow

  • 1Institute for Medical Psychology, University of Munich, Munich, Germany. roenneberg@lmu.de

Journal of Biological Rhythms
|September 30, 2010
PubMed
Summary
This summary is machine-generated.

A new circadian integrated response characteristic (CIRC) model explains biological clock entrainment in Neurospora. This approach unifies previous findings and highlights the role of internal cycle length (τ(E)) in adapting to environmental cues.

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Parallel Measurement of Circadian Clock Gene Expression and Hormone Secretion in Human Primary Cell Cultures
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Parallel Measurement of Circadian Clock Gene Expression and Hormone Secretion in Human Primary Cell Cultures

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Last Updated: Jun 8, 2026

Collecting Sleep, Circadian, Fatigue, and Performance Data in Complex Operational Environments
08:36

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Published on: August 8, 2019

Parallel Measurement of Circadian Clock Gene Expression and Hormone Secretion in Human Primary Cell Cultures
06:53

Parallel Measurement of Circadian Clock Gene Expression and Hormone Secretion in Human Primary Cell Cultures

Published on: November 11, 2016

Area of Science:

  • Chronobiology
  • Circadian Rhythms
  • Molecular Biology

Background:

  • Traditional models struggle to explain biological clock entrainment across all conditions.
  • Existing methods often require extrapolations from constant conditions to entrained states.

Purpose of the Study:

  • To develop a novel approach for understanding circadian clock entrainment.
  • To create a model that explains entrainment without assuming specific mechanisms like phase shifts or velocity changes.

Main Methods:

  • Developed a circadian integrated response characteristic (CIRC) model.
  • Modeled entrainment by adjusting CIRC shape, asymmetry, and internal cycle length under entrainment (τ(E)).
  • Applied the CIRC model to experimental data from Neurospora crassa.

Main Results:

  • The CIRC model successfully explains and unifies entrainment data for Neurospora.
  • Demonstrated that τ(E) is a critical variable in the entrainment process.
  • Showed that the wild-type Neurospora strain is well-tuned for natural 24-h cycles.

Conclusions:

  • The CIRC model offers a unified framework for understanding circadian entrainment.
  • τ(E) plays a significant role in how biological clocks adapt to environmental cycles.
  • This new approach simplifies modeling and provides deeper mechanistic insights.