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Updated: Jun 8, 2026

Technique of Conjunctival Biopsy and Direct Immunofluorescence for Diagnosing Mucous Membrane Pemphigoid

Technique of Conjunctival Biopsy and Direct Immunofluorescence for Diagnosing Mucous Membrane Pemphigoid

Published on: June 17, 2025

Brunsting perry cicatricial pemphigoid.

R R Mittal¹, J Kullar, P S Sethi

¹Department of Skin and VD, Government Medical College, Patiala (Punjab), India.

Indian Journal of Dermatology, Venereology and Leprology

|September 30, 2010

Summary

Two rare cases of Brunsting Perry cicatricial pemphigoid were diagnosed after initial misclassification. Biopsies and immunofluorescence confirmed the condition, and both patients responded well to dapsone treatment.

Area of Science:

Dermatology
Immunodermatology

Background:

Brunsting Perry cicatricial pemphigoid is a rare autoimmune blistering disease.
It can present with non-specific vesiculobullous lesions, complicating early diagnosis.

Purpose of the Study:

To report two rare cases of Brunsting Perry cicatricial pemphigoid.
To highlight diagnostic challenges and treatment outcomes.

Main Methods:

Clinical presentation and history.
Repeated skin biopsies with histopathological examination.
Direct and indirect immunofluorescence studies.
Therapeutic trial with dapsone.

Main Results:

Initial clinical diagnosis was challenging, with cases initially considered typical vesiculobullous disorders.

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Histopathology revealed dermoepidermal junction split, fibrosis, and perivascular mononuclear infiltrate.

Immunofluorescence confirmed cicatricial pemphigoid.

Both patients showed a favorable response to dapsone therapy.

Conclusions:

Brunsting Perry cicatricial pemphigoid requires thorough investigation, including serial biopsies and immunofluorescence, for accurate diagnosis.
Dapsone is an effective treatment option for this rare condition.