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Related Concept Videos

Recycling Endosomes and Transcytosis00:58

Recycling Endosomes and Transcytosis

The recycling endosome, also known as the endosomal recycling compartment (ERC), is a part of the slow-recycling process of the endocytic pathway. Molecules internalized through receptor-mediated endocytosis are either degraded in the lysosomes or are recycled to the plasma membrane through the fast- or slow-recycling route.
The recycling endosome is not a single organelle but an extensively tubulated network of recycling pathways. It functions in storing molecules or transporting them across...
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Flippase
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Image-Based Methods to Study Membrane Trafficking Events in Stomatal Lineage Cells
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Membrane redistributions through multi-intercellular exchanges and serial trogocytosis.

Estibaliz Alegre1, Kiave-Yune Howangyin, Benoit Favier

  • 1Department of Biochemistry, University Clinic of Navarra, Pamplona, Spain.

Cell Research
|September 30, 2010
PubMed
Summary
This summary is machine-generated.

Immune cells like T cells and monocytes can take up membrane patches from tumor cells through trogocytosis. Monocytes show superior capabilities, transferring tumor cell membranes to T cells.

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Area of Science:

  • Immunology
  • Cell Biology
  • Cancer Research

Background:

  • Trogocytosis, the transfer of cell membranes and proteins, is typically studied in simple two-cell systems.
  • Understanding trogocytosis in complex cellular environments is crucial for immune response and cancer research.

Purpose of the Study:

  • To investigate trogocytosis in a complex system involving multiple immune cell subsets and tumor cells.
  • To characterize the membrane exchange capabilities of different immune cells with tumor cells and among themselves.

Main Methods:

  • Studied trogocytosis in a multi-cell system including CD4(+) T cells, CD8(+) T cells, monocytes, and tumor cells.
  • Analyzed membrane acquisition and transfer using advanced cellular imaging and analysis techniques.

Main Results:

  • CD4(+) T cells, CD8(+) T cells, and monocytes acquire membrane patches from multiple tumor cells via simultaneous trogocytosis.
  • Monocytes exhibit superior trogocytic capabilities compared to T cells.
  • Activated peripheral-blood mononuclear cells (PBMCs) undergo self-membrane exchange.
  • Monocytes perform serial trogocytosis, transferring tumor cell membranes to T cells.

Conclusions:

  • Immune effector cells extensively exchange membranes with their environment, including tumor cells.
  • The cellular context significantly influences immune effector cell function through membrane exchange.