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The MAP3K TAK1: a chock block to liver cancer formation

Yann Malato1, Holger Willenbring

  • 1Eli and Edythe Broad Center for Regeneration Medicine and Stem Cell Research, Department of Surgery, Division of Transplantation University of California San Francisco San Francisco, CA, USA.

Hepatology (Baltimore, Md.)
|September 30, 2010
PubMed
Abstract

No abstract available in PubMed .

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MAPK Signaling Cascades01:07

MAPK Signaling Cascades

Mitogen-activated protein kinase, or MAPK pathway, activates three sequential kinases to regulate cellular responses such as proliferation, differentiation, survival, and apoptosis. The canonical MAPK pathway starts with a mitogen or growth factor binding to an RTK. The activated RTKs stimulate Ras, which recruits Raf or MAP3 Kinase (MAPKKK), the first kinase of the MAPK signaling cascade. Raf further phosphorylates and activates MEK or MAP2 Kinases (MAPKK), which in turn phosphorylates MAP...

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