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Updated: Jun 8, 2026
06:01
A Thrombotic Stroke Model Based On Transient Cerebral Hypoxia-ischemia
Published on: August 18, 2015
[Prothrombotic disturbances in children after ischemic stroke].
Zhurnal Nevrologii I Psikhiatrii Imeni S.S. Korsakova
|September 30, 2010
Summary
Children with ischemic stroke have a higher prevalence of prothrombotic gene mutations and elevated homocysteine levels. Screening for these factors and managing homocysteine with vitamins B6, B12, and diet is recommended.
Area of Science:
- Pediatric Neurology
- Hematology
- Genetics
Context:
- Ischemic stroke in children is a significant neurological event.
- Prothrombotic genetic factors are implicated in stroke pathogenesis.
- Understanding these factors in pediatric populations is crucial for diagnosis and management.
Purpose:
- To investigate the frequency of common prothrombotic polymorphisms in children with ischemic stroke.
- To assess homocysteine levels and coagulogram parameters in these patients.
- To identify potential risk factors and inform screening strategies.
Summary:
- A study of 36 children with stroke and 28 controls revealed a 2.8-fold higher incidence of prothrombotic mutations (e.g., MTHFR C677T, MTRR A66G) in the stroke group.
- Elevated homocysteine levels were observed in stroke patients, particularly in carriers of risk genotypes.
- Coagulogram analysis showed deficiencies in protein C, protein S, and antithrombin III, along with increased D-dimer levels.
Impact:
- Findings suggest screening for prothrombotic states and measuring homocysteine in children with ischemic stroke.
- Recommendations include lowering homocysteine levels through vitamin B6, B12 supplementation, and dietary modifications.
- This research contributes to improved diagnostic and therapeutic approaches for pediatric stroke.
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