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A Thrombotic Stroke Model Based On Transient Cerebral Hypoxia-ischemia
06:01

A Thrombotic Stroke Model Based On Transient Cerebral Hypoxia-ischemia

Published on: August 18, 2015

[Prothrombotic disturbances in children after ischemic stroke]

V P Zykov, I B Komarova, S A Vasil'ev

    Zhurnal Nevrologii I Psikhiatrii Imeni S.S. Korsakova
    |September 30, 2010
    PubMed

    Insights

    Children with ischemic stroke have a higher prevalence of prothrombotic gene mutations and elevated homocysteine levels. Screening for these factors and managing homocysteine with vitamins B6, B12, and diet is recommended.

    Area of Science:

    • Pediatric Neurology
    • Hematology
    • Genetics

    Context:

    • Ischemic stroke in children is a significant neurological event.
    • Prothrombotic genetic factors are implicated in stroke pathogenesis.
    • Understanding these factors in pediatric populations is crucial for diagnosis and management.

    Purpose:

    • To investigate the frequency of common prothrombotic polymorphisms in children with ischemic stroke.
    • To assess homocysteine levels and coagulogram parameters in these patients.
    • To identify potential risk factors and inform screening strategies.

    Summary:

    • A study of 36 children with stroke and 28 controls revealed a 2.8-fold higher incidence of prothrombotic mutations (e.g., MTHFR C677T, MTRR A66G) in the stroke group.
    • Elevated homocysteine levels were observed in stroke patients, particularly in carriers of risk genotypes.
    • Coagulogram analysis showed deficiencies in protein C, protein S, and antithrombin III, along with increased D-dimer levels.

    Impact:

    • Findings suggest screening for prothrombotic states and measuring homocysteine in children with ischemic stroke.
    • Recommendations include lowering homocysteine levels through vitamin B6, B12 supplementation, and dietary modifications.
    • This research contributes to improved diagnostic and therapeutic approaches for pediatric stroke.

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