Quantification of prostate deformation due to needle insertion during TRUS-guided biopsy

Prostate biopsy is the clinical standard for the diagnosis of prostate cancer, and technologies for 3D guidance to targets and recording of biopsy locations are promising approaches to reducing the need for repeated biopsies. In this study, we use image-based non-rigid registration to quantify prostate deformation during needle insertion and biopsy gun firing, in order to provide information useful to the overall assessment of a TRUS-guided biopsy system's expected targeting error. We recorded mean tissue displacements of up to 0.4 mm, accounting for 16% of the clinically-motivated maximum desired RMS error of a guidance system.