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Treatment Resistent Cancers02:56

Treatment Resistent Cancers

Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
Treatment Resistant Cancers02:56

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Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
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Drug distribution in the pediatric population exhibits unique challenges and considerations due to the physiological differences between children, particularly neonates and infants, and adults. A crucial aspect of pediatric pharmacology is understanding how these differences impact the pharmacokinetics of various drugs, necessitating age-specific dosing strategies to ensure efficacy and safety.Neonates and infants have a higher total body water content, ~75%–90% of their body weight, compared...
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Understanding the physiological differences in the pediatric population is crucial for effective pharmacotherapy. Neonates, infants, and children exhibit significant variations in gastric pH, gastric emptying time, intestinal transit time, and biliary function. These variations profoundly affect oral drug absorption, necessitating a nuanced approach to pediatric dosing.Neonates present with a unique physiological profile, having a gastric pH greater than 4 and faster and more irregular gastric...
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Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
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Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
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Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies
08:34

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies

Published on: February 6, 2019

Paediatric interventional oncology.

D J Roebuck1

  • 1Department of Radiology, Great Ormond Street Hospital, London, UK. roebud@gosh.nhs.uk

Cancer Imaging : the Official Publication of the International Cancer Imaging Society
|October 1, 2010
PubMed
Summary
This summary is machine-generated.

Interventional radiology (IR) techniques for pediatric cancer are adopted slower than in adults. Key applications in children include biopsy, regional therapy, and supportive care.

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Area of Science:

  • Pediatric Oncology
  • Interventional Radiology

Background:

  • Interventional radiology (IR) techniques are increasingly used in oncology.
  • Adoption of newer IR techniques in pediatric oncology lags behind adult practice.

Purpose of the Study:

  • To review the applications of interventional radiology in pediatric cancer care.
  • To discuss the specific uses of IR in children with cancer.

Main Methods:

  • Review of interventional radiology applications in pediatric oncology.
  • Categorization of IR techniques into biopsy, regional therapy, and supportive care.

Main Results:

  • Interventional radiology plays a role in pediatric cancer management.
  • Key applications include diagnostic biopsies, targeted regional therapies, and supportive care for complications.

Conclusions:

  • Interventional radiology offers valuable tools for managing childhood cancers.
  • Further integration of IR techniques can enhance treatment outcomes for pediatric cancer patients.