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Related Concept Videos

Treatment Resistent Cancers02:56

Treatment Resistent Cancers

Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
Treatment Resistant Cancers02:56

Treatment Resistant Cancers

Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
Cancer Therapies02:49

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
Cancer Therapies02:49

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...

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Related Experiment Video

Updated: Jun 8, 2026

Looking for Driver Pathways of Acquired Resistance to Targeted Therapy: Drug Resistant Subclone Generation and Sensitivity Restoring by Gene Knock-down
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Looking for Driver Pathways of Acquired Resistance to Targeted Therapy: Drug Resistant Subclone Generation and Sensitivity Restoring by Gene Knock-down

Published on: December 11, 2017

Trastuzumab cardio-oncology: lessons learned.

Cynthia Frankel1

  • 1Memorial Cancer Institute, Hollywood, FL, USA. cfrankel@mhs.net

Clinical Journal of Oncology Nursing
|October 1, 2010
PubMed
Summary

Trastuzumab improves outcomes for HER2-positive breast cancer but carries a risk of cardiac dysfunction. Careful patient evaluation and monitoring can mitigate this risk, allowing continued treatment.

Area of Science:

  • Oncology
  • Cardiology
  • Pharmacology

Background:

  • Trastuzumab is a key therapy for HER2-positive breast cancer.
  • A subset of patients experience cardiac dysfunction with trastuzumab treatment.
  • HER2 signaling in cardiomyocytes may be crucial for cardioprotection.

Purpose of the Study:

  • To review the cardiac risks associated with trastuzumab.
  • To outline strategies for mitigating trastuzumab-induced cardiotoxicity.
  • To discuss management of cardiac dysfunction during trastuzumab therapy.

Main Methods:

  • Review of existing literature on trastuzumab and cardiac function.
  • Analysis of risk factors for trastuzumab-associated cardiotoxicity.
  • Discussion of monitoring and intervention strategies.

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Percutaneous Contrast Echocardiography-guided Intramyocardial Injection and Cell Delivery in a Large Preclinical Model
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Percutaneous Contrast Echocardiography-guided Intramyocardial Injection and Cell Delivery in a Large Preclinical Model

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Published on: January 21, 2018

Main Results:

  • Trastuzumab significantly improves outcomes in HER2-positive breast cancer.
  • Cardiac dysfunction is a known, albeit uncommon, side effect.
  • Pre-treatment risk factor assessment and ongoing cardiac monitoring are vital.
  • Early intervention can allow for trastuzumab re-initiation.

Conclusions:

  • Proactive cardiac risk assessment and monitoring are essential for patients receiving trastuzumab.
  • Management strategies can minimize cardiac risks and optimize treatment.
  • Nonanthracycline regimens may benefit cardiac-compromised patients.