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Related Concept Videos

Neuroplasticity01:01

Neuroplasticity

Neuroplasticity reflects the brain's remarkable capacity to adapt and evolve, responding dynamically to learning, experiences, or injury by reorganizing its neural circuitry. This reorganization involves creating new neural connections and refining old ones through a series of biological processes that contribute to the brain's lifelong development and adaptability.
Long-term Potentiation01:25

Long-term Potentiation

Long-term potentiation, or LTP, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTP is the process of synaptic strengthening that occurs over time between pre and postsynaptic neuronal connections. The synaptic strengthening of LTP works in opposition to the synaptic weakening of long-term depression (LTD) and together are the main mechanisms that underlie learning and memory.
Hebbian LTP
LTP can occur when presynaptic neurons...
Long-term Potentiation01:35

Long-term Potentiation

Long-term potentiation, or LTP, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTP is the process of synaptic strengthening that occurs over time between pre- and postsynaptic neuronal connections. The synaptic strengthening of LTP works in opposition to the synaptic weakening of long-term depression (LTD) and together are the main mechanisms that underlie learning and memory.
Synaptic Signaling01:09

Synaptic Signaling

Neurons communicate at synapses, or junctions, to excite or inhibit the activity of other neurons or target cells, such as muscles. Synapses may be chemical or electrical.
Most synapses are chemical, meaning an electrical impulse or action potential spurs the release of chemical messengers called neurotransmitters. The neuron sending the signal is called the presynaptic neuron, and the neuron receiving the signal is the postsynaptic neuron.
The presynaptic neuron fires an action potential that...
Synaptic Signaling01:12

Synaptic Signaling

Neurons communicate at synapses, or junctions, to excite or inhibit the activity of other neurons or target cells, such as muscles. Synapses may be chemical or electrical.
The Synapse02:47

The Synapse

Neurons communicate with one another by passing on their electrical signals to other neurons. A synapse is the location where two neurons meet to exchange signals. At the synapse, the neuron that sends the signal is called the presynaptic cell, while the neuron that receives the message is called the postsynaptic cell. Note that most neurons can be both presynaptic and postsynaptic, as they both transmit and receive information.

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Updated: Jun 8, 2026

3D Modeling of Dendritic Spines with Synaptic Plasticity
07:13

3D Modeling of Dendritic Spines with Synaptic Plasticity

Published on: May 18, 2020

Building and remodeling synapses.

Deanna L Benson1, George W Huntley

  • 1Fishberg Department of Neuroscience and Friedman Brain Institute, Mount Sinai School of Medicine, New York, New York 10029, USA. deanna.benson@mssm.edu

Hippocampus
|October 1, 2010
PubMed
Summary
This summary is machine-generated.

Cell adhesion molecules (CAMs) form synaptic junctions, but their precise roles in synapse structure and plasticity are unclear. Regulated extracellular proteolysis actively drives synaptic remodeling for persistent network changes.

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Area of Science:

  • Neuroscience
  • Cell Biology
  • Molecular Biology

Background:

  • Synaptic junctions rely on adhesion proteins to connect pre- and postsynaptic membranes.
  • The specific contributions of different cell adhesion molecule (CAM) families to synapse formation and structure are not fully understood.
  • The role of smaller, cooperative CAM units in establishing synaptic structure requires further investigation.

Purpose of the Study:

  • To elucidate the functional roles of various CAM families in synapse development and mature structure.
  • To explore how CAMs form minimal, cooperative adhesive units.
  • To understand the mechanisms underlying synaptic remodeling during plasticity.

Main Methods:

  • Investigating the localization and function of synaptic CAMs.
  • Analyzing synapse structure and composition during development and in mature networks.
  • Examining the role of extracellular proteolysis in synaptic plasticity and remodeling.

Main Results:

  • Synapse structure and function change throughout development, with mature synapses being more complex.
  • Mature synapses are influenced by extracellular matrix and astrocytic interactions.
  • Regulated extracellular proteolysis plays a proactive role in driving synaptic modifications.

Conclusions:

  • Synaptic CAMs are crucial for synapse formation and structural integrity.
  • Extracellular proteolysis is a key mechanism for synaptic remodeling and plasticity.
  • Understanding these processes is vital for comprehending persistent changes in neural network activity.