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Updated: Jun 8, 2026
Derivation of Hematopoietic Stem Cells from Murine Embryonic Stem Cells
Published on: February 25, 2007
Dieckol rescues mice from lethal irradiation by accelerating hemopoiesis and curtailing immunosuppression
Eunjin Park1, Ginnae Ahn, Jin-Suk Yun
1Jeju National University, South Korea.
Purpose:
To evaluate the radioprotective effect of dieckol, a component of the brown algae Ecklonia cava.
Materials And Methods:
Mice were lethally irradiated, treated with dieckol and surveyed for survival and the mechanism of radioprotection.
Results:
Dieckol treatment lengthened the survival of irradiated mice and significantly accelerated the hemopoietic recovery of bone marrow cells and peripheral immune cells compared with irradiated, but untreated controls. Dieckol also enhanced the proliferation and differentiation of immune cells, which had been suppressed by ionising radiation. It turned out that the increased expression of oxygen radical-scavenging enzyme manganese superoxide dismutase (MnSOD) and subsequent reduction in DNA damage and lipid peroxidation was crucial for dieckol's radioprotective effect. In addition, the dieckol-induced modulation of protein 53 (p53)-dependent pathways further strengthened the radioresistance of immune cells.
Conclusion:
Dieckol can be a promising agent for reducing the time needed for reconstitution of hemopoietic cells after exposure to irradiation.
