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Aspirin resistance in hypertensive patients
Beste Ozben1, Azra M Tanrikulu, Tomris Ozben
1Department of Cardiology, Marmara University Faculty of Medicine, Istanbul, Turkey. bestes@doctor.com
Journal of Clinical Hypertension (Greenwich, Conn.)
|October 2, 2010
Summary
Aspirin resistance, a condition linked to poor outcomes, was found in 42 of 200 hypertensive patients. Female gender, higher creatinine, and lower platelet count predict this resistance.
Area of Science:
- Cardiology
- Clinical Pharmacology
- Hypertension Management
Background:
- Aspirin resistance is a growing concern, linked to adverse clinical outcomes.
- Understanding predictors of aspirin resistance in specific patient populations is crucial for effective treatment.
Purpose of the Study:
- To investigate the prevalence and predictors of aspirin resistance in hypertensive patients.
- To identify patient characteristics associated with aspirin resistance.
Main Methods:
- Aspirin resistance was assessed in 200 hypertensive patients using the Ultegra Rapid Platelet Function Assay-ASA.
- Aspirin resistance was defined as an aspirin reaction unit ≥550.
- Multivariate analysis was employed to identify independent predictors.
Main Results:
- Aspirin resistance was detected in 42 patients (21%).
- Higher female gender prevalence, elevated creatinine levels, and lower platelet counts were significantly associated with aspirin resistance.
- Female gender (OR, 2.445), creatinine levels (OR, 1.297), and platelet count (OR, 0.993) were independent predictors.
Conclusions:
- Aspirin resistance is prevalent in hypertensive patients.
- Female hypertensive patients with elevated creatinine and low platelet counts face a higher risk of aspirin resistance.
- These findings highlight the need for personalized aspirin therapy monitoring in at-risk hypertensive individuals.
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