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Drug Toxicity: Allergic Reactions

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Related Experiment Video

Updated: Jun 8, 2026

Imaging CD4 T Cell Interstitial Migration in the Inflamed Dermis

Imaging CD4 T Cell Interstitial Migration in the Inflamed Dermis

Published on: March 25, 2016

Intertriginous lymphomatoid drug eruption.

Ronni Wolf¹, Aviv Barzilai, Batya Davidovici

¹The Dermatology Unit, Kaplan Medical Center, Rechovot, Israel. wolf_r@netvision.net.il

International Journal of Dermatology

|October 2, 2010

Summary

A rare drug eruption, termed baboon syndrome, presented with a lymphomatoid drug eruption in a lung cancer patient undergoing chemotherapy. This unusual presentation resolved after changing the chemotherapy regimen.

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Area of Science:

Dermatology
Oncology
Pathology

Background:

Lung cancer patients undergoing chemotherapy are susceptible to adverse cutaneous reactions.
Chemotherapy regimens, including cisplatinum and gemcitabine, can trigger various drug eruptions.

Observation:

A 76-year-old man presented with a maculopapular purpuric eruption localized to intertriginous areas.
Histological examination suggested either lymphomatoid drug eruption or lymphomatoid papulosis.
The eruption appeared after receiving cisplatinum and gemcitabine for stage III B lung squamous cell carcinoma.

Findings:

The patient's eruption resolved completely within two weeks after switching chemotherapy to vinorelbine.
Circumstantial evidence strongly supports a diagnosis of intertriginous drug eruption, also known as baboon syndrome.
This case represents a rare instance of baboon syndrome with histological features mimicking lymphoma.

Implications:

This case highlights the importance of recognizing rare drug eruption presentations in oncology patients.
The findings suggest a potential link between specific chemotherapy agents and baboon syndrome.
Further research is needed to elucidate the pathomechanisms of baboon syndrome and lymphomatoid drug eruptions.