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Determination of antitubercular drugs in human plasma by HPLC through direct injection
C Altomare1, A Carotti, S Cellamare
1Dipartimento Farmaco-Chimico, Università di Bari, Italy.
Farmaco (Societa Chimica Italiana : 1989)
|November 1, 1990
Abstract:
A simple and efficient method is described for the direct determination of Isoniazide (INH) and Pyrazinamide (PZAm) in human plasma, based on reversed-phase HPLC. A number of other antitubercular drugs such as p-Aminosalycylic acid (PAS), Streptomycin (STM) and Ethambutol (ETH) and the major metabolites of the two investigated drugs, namely N-Monoacetylisoniazide (AcINH) and Pyrazinoic acid (PZAc), were shown not to interfere with the assay method. A potential application of the method to routine clinical monitoring of antitubercular drugs is discussed.