Related Experiment Video
Updated: Jun 8, 2026

13:31
A Neonatal Mouse Spinal Cord Compression Injury Model
Published on: March 27, 2016
Children with spina bifida: key clinical issues
1Olson Huff Center, Mission Children's Hospital, 11 Vanderbilt Park Drive, Asheville, NC 28803, USA. adsandler@pol.net
Pediatric Clinics of North America
|October 2, 2010
Summary
Spina bifida, a common neural tube defect, involves incomplete vertebral arches and causes various impairments. This article details associated sensory, motor, neurologic, orthopedic, and cognitive issues in affected children.
Area of Science:
- Developmental Biology
- Pediatric Neurology
- Clinical Medicine
Background:
- Spina bifida is the most prevalent neural tube defect.
- It is a complex, multisystem birth defect characterized by incomplete vertebral arches.
- Other neural tube defects include myelomeningocele, encephalocele, and anencephaly.
Purpose of the Study:
- To discuss the multifaceted impairments associated with spina bifida.
- To summarize key clinical issues in the care of children with spina bifida.
- To provide a comprehensive overview of this complex birth defect.
Main Methods:
- Literature review of spina bifida.
- Discussion of associated sensory and motor impairments.
- Summary of neurologic, orthopedic, and cognitive deficits.
Main Results:
- Spina bifida presents with a range of sensory and motor deficits.
- Neurologic, orthopedic, and cognitive impairments are common.
- Associated skin and other problems require management.
- Children with spina bifida face complex clinical care challenges.
Conclusions:
- Spina bifida necessitates a comprehensive understanding of its multisystemic effects.
- Effective management requires addressing diverse impairments and clinical issues.
- Multidisciplinary care is crucial for optimizing outcomes in children with spina bifida.
Related Concept Videos
Neurulation
Neurulation is the embryological process which forms the precursors of the central nervous system and occurs after gastrulation has established the three primary cell layers of the embryo: ectoderm, mesoderm, and endoderm. In humans, the majority of this system is formed via primary neurulation, in which the central portion of the ectoderm—originally appearing as a flat sheet of cells—folds upwards and inwards, sealing off to form a hollow neural tube. As development proceeds, the anterior...
Spinal Cord Injury ll: Pathophysiology
Spinal cord injury progresses through two interconnected phases: primary injury and secondary injury.Primary InjuryPrimary injury happens at the moment of trauma and involves immediate mechanical damage to the spinal cord.Compression happens when broken vertebrae, herniated discs, or accumulating blood (such as a hematoma) press directly against the spinal cord, distorting its normal shape and function. In cases of contusion, the cord is bruised by a blunt force (like penetrating injuries or...
Secondary Spinal Cord Injury llI: Pathophysiology
Early Ischemia and Ionic ImbalanceWithin minutes of spinal cord injury, a secondary cascade begins, progressing over hours to weeks. Vascular damage reduces blood flow, causing ischemia and mitochondrial dysfunction. ATP depletion leads to ion pump failure, membrane depolarization, sodium influx, potassium efflux, and water accumulation, resulting in cellular swelling. Increased intracellular calcium further disrupts mitochondria and accelerates cellular injury.Excitotoxicity and Neuronal...
Teratogenicity
The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...

