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Updated: Jun 8, 2026

A Volumetric Method for Quantification of Cerebral Vasospasm in a Murine Model of Subarachnoid Hemorrhage
08:12

A Volumetric Method for Quantification of Cerebral Vasospasm in a Murine Model of Subarachnoid Hemorrhage

Published on: July 28, 2018

Diagnostic accuracy of CT angiography and CT perfusion for cerebral vasospasm: a meta-analysis

E D Greenberg1, R Gold, M Reichman

  • 1Department of Radiology, Weill Cornell Medical College, New York-Presbyterian Hospital, New York, New York 10021, USA. edg2008@nyp.org

AJNR. American Journal of Neuroradiology
|October 2, 2010
PubMed

Insights

This meta-analysis found that both CT angiography (CTA) and CT perfusion (CTP) demonstrate high diagnostic accuracy for detecting vasospasm in patients with aneurysmal subarachnoid hemorrhage (ASAH). These imaging techniques offer valuable support for clinical decision-making in managing ASAH.

Area of Science:

  • Neurology
  • Radiology
  • Medical Imaging

Background:

  • Vasospasm is a critical complication following aneurysmal subarachnoid hemorrhage (ASAH).
  • Accurate diagnosis of vasospasm is essential for timely intervention and improved patient outcomes.
  • Computed Tomography Angiography (CTA) and Computed Tomography Perfusion (CTP) are increasingly utilized for vasospasm assessment.

Purpose of the Study:

  • To conduct a meta-analysis evaluating the diagnostic performance of CTA and CTP for vasospasm in ASAH patients.
  • To compare the accuracy of CTA and CTP against Digital Subtraction Angiography (DSA) as the reference standard.

Main Methods:

  • Systematic literature search of PubMed, Embase, Cochrane, and Web of Science databases (January 1996 - February 2009).
  • Inclusion of original research studies on patients with ASAH, using CTA or CTP as index tests and DSA as the reference standard.
  • Quality assessment using the QUADAS tool and pooled estimation of diagnostic accuracy metrics (sensitivity, specificity, likelihood ratios, diagnostic odds ratio, SROC curve).

Main Results:

  • Meta-analysis included 6 CTA studies and 3 CTP studies.
  • CTA demonstrated pooled sensitivity of 79.6% and specificity of 93.1%.
  • CTP showed pooled sensitivity of 74.1% and specificity of 93.0%.
  • Both CTA and CTP exhibited high areas under the SROC curve (98% and 97%, respectively).

Conclusions:

  • Both CTA and CTP possess high diagnostic accuracy for vasospasm detection in ASAH.
  • These imaging modalities are valuable tools for diagnosing vasospasm in the context of ASAH.
  • Findings support the effective utilization of CTA and CTP in patient care for ASAH.
Abstract

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