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Updated: Jun 8, 2026

Induction and Validation of Cellular Senescence in Primary Human Cells
Published on: June 20, 2018
p38(MAPK) in the senescence of human and murine fibroblasts
Florence Debacq-Chainiaux1, Emmanuelle Boilan, Jérémie Dedessus Le Moutier
1University of Namur, Research Unit on Cellular Biology, Rue de Bruxelles, 61, Namur B-5000, Belgium. florence.chainiaux@fundp.ac.be
Abstract:
Oncogenic and environmental stresses, such as reactive oxygen species, UV radiation etc, can induce premature cellular senescence without critical telomere shortening. The role of the Ras/Raf/ERK signal transduction cascade in this process has been previously established, but recent evidence also indicates a critical role of the p38 MAP kinases pathway. Oncogenic and environmental stresses impinge upon the p38(MAPK) pathway, suggesting a major role of this pathway in senescence induced by stresses. Prematurely senescent cells are most likely to appear in several age-relatedpathologies associated with a stressful environment and/or the release of pro-inflammatory cytokines.
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