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Quantitative assessment of scleroderma by surface wave technique.

Xiaoming Zhang1, Thomas G Osborn, Mark R Pittelkow

  • 1Department of Physiology and Biomedical Engineering, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905, USA. zhang.xiaoming@mayo.edu

Medical Engineering & Physics
|October 5, 2010
PubMed
Summary

This study introduces a new method to objectively measure skin properties in scleroderma patients by analyzing surface waves. This technique offers a quantitative approach to evaluate skin viscoelasticity, improving upon subjective manual scoring methods.

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Area of Science:

  • Biomedical Engineering
  • Dermatology
  • Rheumatology

Background:

  • Scleroderma is a multisystem disease causing fibrosis, with skin involvement being a key feature and predictor of visceral disease.
  • Current skin assessment relies on the modified Rodnan skin score (MRSS), a subjective manual method.
  • There is a need for objective, quantitative methods to assess skin changes in scleroderma.

Purpose of the Study:

  • To develop and validate a novel technique for quantitatively assessing human skin viscoelasticity.
  • To evaluate the feasibility of using surface wave analysis to differentiate between healthy subjects and scleroderma patients.

Main Methods:

  • A system was developed to generate and analyze surface waves in the skin using a mechanical shaker, force transducer, and scanning laser vibrometer.
  • Skin viscoelastic properties were measured in 30 healthy volunteers and 10 scleroderma patients across six anatomical sites.
  • Surface wave speed and dispersion were analyzed to estimate shear elasticity and viscosity.

Main Results:

  • Surface wave speed measurements were consistent, with a typical value of 3.25±0.19 m/s on the forearm at 200 Hz.
  • Shear elasticity and viscosity were estimated as 7.86±1.86 kPa and 5.03±0.60 Pa, respectively, on the forearm.
  • Statistical analysis revealed significant differences in skin viscoelasticity between scleroderma patients and healthy individuals.

Conclusions:

  • The developed technique provides an effective and quantitative method for evaluating scleroderma based on skin viscoelastic properties.
  • This approach offers an objective alternative to the subjective modified Rodnan skin score (MRSS).
  • Surface wave analysis holds promise for improved diagnosis and monitoring of scleroderma.