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Related Experiment Video

Updated: Jun 8, 2026

Detection of Intracellular Gene Expression in Live Cells of Murine, Human and Porcine Origin Using Fluorescence-labeled Nanoparticles

Detection of Intracellular Gene Expression in Live Cells of Murine, Human and Porcine Origin Using Fluorescence-labeled Nanoparticles

Published on: November 13, 2015

Nanoplasmonic gene regulation.

Somin Eunice Lee¹, Luke P Lee

¹Department of Bioengineering, University of California-Berkeley, UCSF/UCB Joint Graduate Group in Bioengineering, Berkeley Sensor & Actuator Center, Berkeley, CA, USA.

Current Opinion in Chemical Biology

|October 5, 2010

Summary

This summary is machine-generated.

Recent nanoplasmonic tools offer precise, remote control over gene expression. These nanoplasmonic carriers deliver DNA/RNA for on-demand gene silencing or introduction, enabling new intracellular genetic studies.

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Published on: May 28, 2016

Area of Science:

Biomedical Engineering
Molecular Biology
Nanotechnology

Background:

Gene regulation is crucial for cellular function and disease.
Conventional gene manipulation methods face limitations in precision and control.
Nanoplasmonics offers novel approaches for targeted intracellular interventions.

Purpose of the Study:

To review recent advancements in nanoplasmonic gene regulation.
To describe nanoplasmonic carriers and their genetic cargo.
To highlight strategies for on-demand gene silencing and expression.

Main Methods:

Utilizing nanoplasmonic carriers for DNA/RNA delivery.
Employing near-infrared (NIR) light for controlled cargo release.
Developing nanoplasmonic optical switches for gene manipulation.
Implementing advanced nanoplasmonic optics for intracellular probing.

Main Results:

Demonstrated on-demand silencing of endogenous genes.
Showcased on-demand introduction and expression of exogenous genes.
Achieved systematic remote control over gene activity magnitude and timing.
Enabled quantitative analysis of intracellular dynamics previously inaccessible.

Conclusions:

Nanoplasmonic technologies provide unprecedented remote control over intracellular gene expression.
These tools facilitate precise, on-demand modulation of genetic activities.
Future quantitative studies using nanoplasmonic optics will advance understanding of living systems.