Related Experiment Videos
Coarse-grained models: getting more with less
1Department of Physics, 402N. Blackford St., LD154D, Indiana University-Purdue University Indianapolis, Indianapolis, IN 46202, USA. ajrader@iupui.edu
Abstract:
There has recently been a proliferation of simplified, coarse-grained models to study aspects of biomolecular dynamics, binding, assembly and folding. Despite differences in construction these various coarse-grained models share a common underlying desire to identify the minimal set of variables required to realistically describe the essence of these molecules. Recent results emphasizing common and distinctive features are highlighted. For someone not involved in developing such models it is a daunting task to decide which, if any, coarse-grained model would be appropriate for a given system. Although this decision ultimately depends upon what kinds of questions one is probing, suggestions about reaching a conclusion are provided.
Related Concept Videos
Multicompartment Models: Overview
These models offer a more comprehensive representation of drug behavior in the body than one-compartment models. They accommodate the complexity of drug distribution,...
Mechanistic Models: Compartment Models in Algorithms for Numerical Problem Solving
In individual population analyses, different algorithms are employed, such as Cauchy's method, which uses a...
Mechanistic Models: Overview of Compartment Models
Clearance Models: Noncompartmental Models
The noncompartmental approach capitalizes on extensive sampling data, correlating the volume of distribution to systemic exposure and the administered dosage. This method enables...
Mechanistic Models: Compartment Models in Individual and Population Analysis
Clearance Models: Compartment Models