Development and analysis of a collagen-based hemostatic adhesive

Area of Science:

• Biomaterials Science
• Surgical Innovation
• Hemostasis Research

Background:

• Commercially available hemostatic adhesives carry disease transmission risks due to plasma-derived components.
• Development of novel, safer hemostatic agents is crucial for clinical applications.

Purpose of the Study:

• To synthesize and evaluate the performance of two new atelocollagen-based hemostatic adhesives.
• To compare the hemostatic and adhesion capabilities of the novel agents against control groups.

Main Methods:

• Two atelocollagen-based adhesives, Bleestop A and Bleestop B, were formulated with specific components.
• Performance was assessed in an adult male Sprague-Dawley rat liver model using adhesion strength tests and histologic evaluation.
• Comparison was made against a negative control (no adhesive) and a positive control (Tissucol Duo Quick).

Main Results:

• Bleeding was controlled immediately with Bleestop A; >95% adhesion achieved within 1 min.
• Bleestop B achieved >95% adhesion within 45 s.
• Both Bleestop A and B demonstrated rapid, organized adhesion and comparable adhesion strength to the positive control after 3 min.

Conclusions:

• Bleestop A and Bleestop B exhibit significant hemostasis and adhesion capabilities within one minute.
• The novel adhesives demonstrate performance comparable to established commercial hemostatic agents.