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Related Experiment Video

Updated: Jun 8, 2026

Chronic Salmonella Infection Induced Intestinal Fibrosis

Chronic Salmonella Infection Induced Intestinal Fibrosis

Published on: September 22, 2019

[Gut microbiota and IBD].

¹Gastroenterology and Nutrition Department, Hôpital Saint Antoine, AP-HP, Paris, France. philippe.seksik@sat.aphp.fr

Gastroenterologie Clinique Et Biologique

|October 5, 2010

Summary

The gut microbiota plays a key role in inflammatory bowel disease (IBD) pathogenesis. Imbalances in gut bacteria, including the expansion of harmful species or loss of beneficial ones, contribute to chronic gut inflammation in IBD.

Area of Science:

Microbiome research
Immunology
Gastroenterology

Context:

The gut microbiota comprises trillions of bacteria crucial for host health.
Inflammatory bowel disease (IBD) involves immune system dysregulation in genetically susceptible individuals.
16S rRNA gene sequencing is a primary method for microbial taxonomy.

Purpose:

To investigate the role of gut microbiota in the pathogenesis of inflammatory bowel disease (IBD).
To explore how bacterial communities contribute to chronic gut inflammation.

Summary:

Experimental models demonstrate bacteria are essential for colitis development.
Germ-free animals typically do not develop IBD, highlighting microbial involvement.
Dysbiosis, an imbalance of gut bacteria, is implicated in IBD, involving expansion of pro-inflammatory species or loss of protective bacteria.

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Injections of Lipopolysaccharide into Mice to Mimic Entrance of Microbial-derived Products After Intestinal Barrier Breach

Injections of Lipopolysaccharide into Mice to Mimic Entrance of Microbial-derived Products After Intestinal Barrier Breach

Published on: May 2, 2018

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Last Updated: Jun 8, 2026

Chronic Salmonella Infection Induced Intestinal Fibrosis

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Published on: September 22, 2019

Injections of Lipopolysaccharide into Mice to Mimic Entrance of Microbial-derived Products After Intestinal Barrier Breach

Injections of Lipopolysaccharide into Mice to Mimic Entrance of Microbial-derived Products After Intestinal Barrier Breach

Published on: May 2, 2018

Impact:

Understanding the gut microbiota's role in IBD can lead to novel therapeutic strategies.
Identifying specific bacterial species or functions involved in IBD pathogenesis is crucial.
This research emphasizes the complex interplay between host genetics, immunity, and the gut microbiome in IBD.