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Rous Sarcoma Virus (RSV) and Cancer01:03

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Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
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Establishment of Cancer Stem Cell Cultures from Human Conventional Osteosarcoma
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Published on: October 14, 2016

Secondary chondrosarcoma.

Patrick P Lin1, Charbel D Moussallem, Michael T Deavers

  • 1Department of Orthopaedic Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, USA.

The Journal of the American Academy of Orthopaedic Surgeons
|October 5, 2010
PubMed
Summary
This summary is machine-generated.

Secondary chondrosarcoma, often arising from osteochondromas, is a malignant cartilage tumor. While prognosis is generally good with surgical treatment, local recurrence is a concern, particularly in pelvic cases.

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Area of Science:

  • Orthopedic Oncology
  • Skeletal Pathology

Background:

  • Secondary chondrosarcoma develops from pre-existing benign cartilage tumors.
  • Osteochondromas are the most common precursor, though Maffucci syndrome and Ollier disease can also be associated.
  • Malignant transformation is indicated by rapid growth of the cartilaginous cap, but a definitive size threshold for malignancy is not established.

Purpose of the Study:

  • To review the characteristics, treatment, and prognosis of secondary chondrosarcoma.
  • To highlight the significance of cartilaginous cap changes in osteochondromas.
  • To identify risk factors for local recurrence.

Main Methods:

  • Review of existing literature on secondary chondrosarcoma.
  • Analysis of clinical presentation and imaging findings.
  • Evaluation of treatment outcomes and recurrence rates.

Main Results:

  • Secondary chondrosarcoma typically arises from osteochondromas.
  • Most tumors are low to intermediate grade with uncommon distant metastasis.
  • Five-year survival is approximately 90%, with surgical resection being the primary treatment.
  • Local recurrence rates range from 10% to 20%, with pelvic tumors posing a higher risk.

Conclusions:

  • Secondary chondrosarcoma is a manageable malignancy with a favorable prognosis.
  • Vigilance for cartilaginous cap enlargement in osteochondromas is crucial for early detection.
  • Wide surgical margins are essential, and awareness of pelvic tumor recurrence risk is important.