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Updated: Jun 8, 2026

A Three-dimensional Tissue Culture Model to Study Primary Human Bone Marrow and its Malignancies
Published on: March 8, 2014
[Cytokines in bone diseases. Cytokines and myeloma bone disease]
1Department of Medicine and Bioregulatory Sciences, University of Tokushima Graduate School of Medicine.
Abstract:
Multiple myeloma develops and expands almost exclusively in the bone marrow, and generates devastating bone destruction. MM cells produce a variety of cytokines to stimulate bone resorption by enhancing osteoclast formation and suppress bone formation by inhibiting osteoblast differentiation, leading to bone destruction and rapid loss of bone. In these lesions, osteoclasts and bone marrow stromal cells/immature osteoblasts create a microenvironment suitable for myeloma cell growth and survival, thereby forming a vicious cycle between bone destruction and myeloma expansion.
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