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Blood-brain barrier disruption following CPR in piglets
C L Schleien1, R C Koehler, D H Shaffner
1Johns Hopkins Medical Institutions, Department of Anesthesiology/Critical Care Medicine, Baltimore, Maryland.
Acta Neurochirurgica. Supplementum
|January 1, 1990
Abstract:
We studied blood-brain barrier (BBB) integrity in immature piglets during the following cardiopulmonary resuscitation (CPR). As in our previous work in the dog, there was no disruption during CPR after eight minutes of cardiac arrest, or immediately following resuscitation using a small molecule, alpha-aminoisobutyric acid. However, unlike the dog, where the BBB remained intact, we found delayed disruption of the BBB four hours after resuscitation. Young animals may be more prone to a delayed increase in BBB permeability after cardiac arrest and CPR.