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Induction of IL-1 by lipopolysaccharide (LPS) and its modulation by synthetic lipid A precursor Ia
1Department of Immunology and Cell Biology, Forschungsinstitut Borstel, FRG.
Abstract:
The synthetic precursor Ia of lipid A (compound 406), lacking dodecanoic and tetradecanoic fatty acids, is inactive in inducing IL-1, but is able to modulate the production and the release of LPS-induced IL-1.