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[Hypertension in the aged person. Numerous questions, few responses]
M Godin1, R Joannides, I Etienne
1Service de Néphrologie, Hôpital de Bois-Guillaume, CHU de Rouen.
Insights
Hypertension is common in older adults and a significant cardiovascular risk. Antihypertensive therapy benefits this group, but treatment decisions for very old individuals and isolated systolic hypertension require further consideration.
Area of Science:
- Gerontology
- Cardiovascular Medicine
- Clinical Pharmacology
Context:
- Blood pressure naturally rises with age, leading to a high prevalence of hypertension in the elderly.
- While true prevalence may be overestimated due to arterial stiffness, hypertension remains a critical risk factor for cardiovascular events in older populations.
Purpose:
- To review the benefits of antihypertensive therapy in the elderly.
- To address ongoing questions regarding the treatment of hypertension in very old individuals, including isolated systolic hypertension and drug selection.
Summary:
- Hypertension is prevalent in the elderly, posing a significant risk for cardiovascular morbidity and mortality.
- Clinical trials demonstrate the benefits of antihypertensive therapy in older adults.
- Key unresolved issues include the justification of treatment in the very old, management of isolated systolic hypertension, optimal drug choices, and diagnostic approaches for renovascular disease.
Impact:
- Provides a comprehensive overview of hypertension management in the elderly.
- Highlights critical areas for future research and clinical decision-making in geriatric hypertension.
- Informs clinical practice regarding the benefits and complexities of treating hypertension in older adults.
Abstract:
Blood pressure levels increase with age. So, the prevalence of both isolated systolic (systolic pressure greater than 160 mmHg and diastolic less than 90 mmHg) and diastolic hypertension (diastolic pressure greater than 95 mmHg) in the elderly is high. Due to high variability of blood pressure and to overestimation of real blood pressure when arterial walls are sclerosed, the true prevalence of hypertension is probably overestimated. Nevertheless, like in younger persons, hypertension in elderly is a major risk factor of cardiovascular morbidity and mortality. Results of clinical trials designed in the last 30 years have clearly proved benefit of antihypertensive therapy. However, a lot of questions remain: Is treating hypertension justified in the very old? Has isolated systolic hypertension to be treated? Which antihypertensive drugs may be used? Is screening for atherosclerotic renovascular disease useful? Which investigations have to be performed for diagnosing atheromatous renal failure?
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