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Morphological changes in the human thyroid gland cultivated in continual flow system
J Velický1, I Sterzl, V Mandys
1Institute of Experimental Medicine, Czechoslovak Academy of Sciences, Prague, CSFR.
Zeitschrift Fur Mikroskopisch-Anatomische Forschung
|January 1, 1990
Summary
This pilot study observed human thyroid tissue in continuous culture. While thyroid hormone secretion remained stable, thyroglobulin secretion decreased over time, suggesting adaptive regeneration.
Area of Science:
- Endocrinology
- Cell Biology
- Tissue Engineering
Background:
- The ACUSYST-S system allows for continuous culture of human thyroid tissue.
- Understanding thyroid tissue behavior in vitro is crucial for research.
Purpose of the Study:
- To evaluate morphological changes in human thyroid tissue during continuous culture.
- To assess the secretion of thyroglobulin (Tgl) and thyroid hormones under these conditions.
Main Methods:
- Human thyroid gland tissue was cultured in ACUSYST-S system chambers.
- Morphological assessments and measurements of Tgl and thyroid hormone secretion were performed.
Main Results:
- Follicular structure showed peripheral preservation with central regressive changes, evolving over 144 hours.
- Thyroid hormone secretion was not significantly affected.
- Thyroglobulin (Tgl) secretion demonstrated a consistent decrease throughout the cultivation period.
Conclusions:
- The observed changes suggest potential functional regeneration and adaptation of thyroid tissue in culture.
- Continuous culture impacts Tgl secretion, indicating altered thyroid gland function in vitro.