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Aging, hormones and receptors

M Hill1, Z Třískala, P Honců

  • 1Department of Steroids and Proteohormones, Institute of Endocrinology, Prague, Czech Republic. mhill@endo.cz.

Physiological Research
|October 23, 2020
PubMed

Insights

Aging brings physical decline and increased disease risk. However, interventions targeting the hypothalamic-pituitary-adrenal axis, alongside lifestyle changes, can mitigate these aging-related changes.

Area of Science:

  • Gerontology and molecular biology, focusing on aging processes and interventions.

Background:

  • Aging involves physiological deterioration and increased susceptibility to diseases.
  • Small molecules play a crucial role in both normal aging and age-related pathologies.
  • The hypothalamic-pituitary-adrenal axis is implicated in age-related functional decline.

Purpose of the Study:

  • To investigate the role of small molecules in aging processes.
  • To explore potential therapeutic strategies for age-related changes.
  • To understand the impact of the hypothalamic-pituitary-adrenal axis on aging.

Main Methods:

  • Review of existing literature on aging, small molecules, and the hypothalamic-pituitary-adrenal axis.
  • Analysis of previously published results and data from other research groups.
  • Focus on physiological and pathophysiological processes associated with aging.

Main Results:

  • Age-related deterioration is significantly influenced by the hypothalamic-pituitary-adrenal axis.
  • Small molecules are key players in aging-related physiological and pathophysiological changes.
  • Evidence suggests that interventions can modify the course of aging.

Conclusions:

  • The negative effects of aging can be slowed, halted, or even reversed.
  • Targeting the hypothalamic-pituitary-adrenal axis offers a promising therapeutic avenue.
  • Lifestyle adjustments are crucial for managing and mitigating age-related decline.

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