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Expression and function of myc family genes
1Department of Biochemistry, Columbia University, New York, New York 10032.
Critical Reviews in Oncogenesis
|January 1, 1990
Summary
The myc gene family, including c-myc, N-myc, and L-myc, plays a role in cell growth and tumorigenesis. Their unique expression patterns during development and in tumors suggest distinct functions in cell regulation.
Area of Science:
- Molecular Biology
- Oncology
- Developmental Biology
Background:
- The myc gene family comprises nuclear oncogenes crucial for cell proliferation and differentiation.
- Members like c-myc, N-myc, and L-myc encode related proteins with roles in tumorigenesis.
- Distinct expression patterns of myc genes correlate with normal development and tumor formation.
Purpose of the Study:
- To review the similar and unique properties of myc gene family members.
- To explore their roles in normal development and cancer.
- To understand their potential function in gene regulation.
Main Methods:
- Literature review of myc gene family research.
- Analysis of gene expression patterns in development and tumors.
- Comparison of myc gene homologies with DNA-binding proteins.
Main Results:
- Myc family members exhibit unique expression profiles during development and in various tumors.
- Changes in myc gene expression are linked to growth and differentiation stimuli.
- Homologies suggest myc proteins function as transcriptional regulators.
Conclusions:
- Myc genes are critical regulators of cellular processes, including development and cell cycle control.
- Dysregulation of myc genes contributes to tumorigenesis.
- Further research into myc gene function is essential for understanding cancer biology.