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Updated: Jun 8, 2026

Integrated Bone Formation Through In Vivo Endochondral Ossification Using Mesenchymal Stem Cells
Published on: July 14, 2023
[Bone and cartilage repair using stem cells]
Kenneth H Larsen1, Tom E Andersen, Moustapha Kassem
1Klinik for Molekylaer Endokrinologi, Endokrinologisk Afdeling M, Odense Universitetshospital, Winsløwparken 25, 1. sal, 5000 Odense C, Denmark.
Abstract:
Mesenchymal stem cells (MSC) are capable of multilineage differentiation into cells like osteoblasts, chondrocytes or adipocytes. MSCs can be isolated from bone marrow and expanded ex vivo for up to 25-40 population doublings while maintaining genetic stability and differentiation potential. MSCs have great potential in the field of tissue engineering and regenerative medicine where cartilage and bone conditions which are non-treatable or show very slow improvement can be effectively handled. Several clinical trials have been performed using MSC and show very promising results.
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