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Influence of laminarin polysaccahrides on oxidative damage
Daye Cheng1, Bin Liang, Mingxin Li
1Transfusion department, The First Hospital of China Medical University, North Nanjing Street No 155, Shenyang 110001, Liaoning Province, PR China. chengdy6s@yahoo.com.cn
International Journal of Biological Macromolecules
|October 6, 2010
Summary
Laminarin polysaccharides from a tropical plant show promise in combating lung oxidative stress. This study found they effectively reduced lipid peroxidation and normalized key antioxidant enzyme activities in rats.
Area of Science:
- Pharmacology
- Biochemistry
- Traditional Chinese Medicine
Background:
- Laminarin, a tropical plant, has a history of use in Traditional Chinese Medicine.
- Oxidative stress and lipid peroxidation are significant factors in lung injury.
Purpose of the Study:
- To analyze the composition of Laminarin polysaccharides.
- To evaluate the efficacy of Laminarin polysaccharides in mitigating lung oxidative stress and lipid peroxidation in a rat model.
Main Methods:
- Gas Chromatography-Mass Spectrometry (GC-MS) was used for polysaccharide composition analysis.
- Rats were divided into control and Laminarin polysaccharide-treated groups.
- Laminarin polysaccharides were administered orally for 14 days.
Main Results:
- Polysaccharide analysis revealed significant fucose content (46.93%).
- Laminarin polysaccharides normalized catalase (CAT) activity (P<0.01).
- Increased glutathione peroxidase (GPx) and superoxide dismutase (SOD) activities were observed.
- Reduced malondialdehyde (MDA) concentrations indicated decreased lipid peroxidation.
Conclusions:
- Laminarin polysaccharides demonstrate significant antioxidant properties.
- They are effective in reducing sepsis-induced oxidative stress and lipid peroxidation in rats.
- Further research into Laminarin's therapeutic potential is warranted.