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Muscles of the Forearm that Move the Hand and Fingers01:16

Muscles of the Forearm that Move the Hand and Fingers

The muscles of the forearm that move the wrist, hand, and digits are numerous and diverse. They can be classified into two groups based on their location and function — the anterior and posterior compartment muscles.
Anterior Compartment
The anterior compartment muscles originate from the humerus. They primarily function as flexors and are also known as flexor muscles. They typically insert on the carpals, metacarpals, and phalanges. The superficial layer includes the flexor carpi radialis,...

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Longitudinal hand function in Rett syndrome.

Jennepher Downs1, Ami Bebbington, Walter E Kaufmann

  • 1Telethon Institute for Child Health Research, Centre for Child Health Research, The University of Western Australia, Perth, Western Australia, Australia.

Journal of Child Neurology
|October 6, 2010
PubMed
Summary
This summary is machine-generated.

Hand function decline in Rett syndrome (RS) affects 40% of girls with grasping skills over time. Younger girls and those with less mobility showed greater loss, highlighting variability in disease progression.

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Area of Science:

  • Neurology
  • Developmental Pediatrics
  • Genetics

Background:

  • Rett syndrome (RS) is a rare neurodevelopmental disorder.
  • Loss of hand function is a primary characteristic of RS.
  • Understanding the progression of hand function is crucial for managing the disorder.

Purpose of the Study:

  • To describe the longitudinal changes in hand function over 3-4 years in individuals with Rett syndrome.
  • To identify factors influencing the rate of hand function decline.

Main Methods:

  • Longitudinal study of 72 subjects with Rett syndrome from the Australian Rett Syndrome Database.
  • Video assessments of hand function at 3 time points over 3-4 years.
  • Analysis of factors including age, mobility, and feeding ability.

Main Results:

  • Approximately 40% of subjects with initial grasping abilities experienced a decline in hand function.
  • Decline was less frequent in older girls (13-19 years) compared to younger ones (<8 years).
  • Subjects with some mobility and those previously able to finger feed showed slower decline compared to wheelchair-bound individuals and those unable to finger feed.

Conclusions:

  • Significant variability exists in the longitudinal course of hand function in Rett syndrome.
  • Age and mobility status are associated with the rate of hand function loss.
  • Further research is needed to understand the mechanisms driving this variability.