Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Autism Spectrum Disorder01:19

Autism Spectrum Disorder

Autism spectrum disorder (ASD) is a neurodevelopmental condition marked by persistent deficits in social communication and interaction alongside restrictive and repetitive behaviors or interests. ASD is sometimes accompanied by intellectual impairment.
These core symptoms manifest differently among individuals, ranging from mild to severe. The disorder's complexity extends beyond its clinical presentation, encompassing a diverse range of biological, cognitive, and sociocultural influences.
Pedigree Analysis01:35

Pedigree Analysis

Overview
Cancer Prevention02:59

Cancer Prevention

Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
Probability Laws01:49

Probability Laws

Overview
Human Genetics01:28

Human Genetics

Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
Teratogenicity01:07

Teratogenicity

The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Cardiometabolic Biomarkers at Age 44-45 in the Psychosis Spectrum: The British National Child Development Study.

Schizophrenia bulletin·2026
Same author

Cognitive impairment preceding the onset of the first psychosis episode in schizophrenia.

Molecular psychiatry·2026
Same author

Perinatal and maternal factors associated with Autism Spectrum Disorder.

PloS one·2026
Same author

Social Isolation and Aging health in Schizophrenia spectrum disorders (SIAS): study protocol for a multinational longitudinal study.

BMC psychiatry·2026
Same author

Whole brain grey matter synaptic terminal density, age and intellectual functioning in schizophrenia: an in vivo [<sup>11</sup>C]UCB-J positron emission tomography study.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology·2026
Same author

Inflammatory markers (IL-6 and CRP) in childhood and their association with brain structure and psychotic experiences in adulthood.

Brain, behavior, and immunity·2026
Same journal

Impact of Transcranial Direct Current Stimulation-Induced Electric Fields on Slowing Cognitive Decline in Older Adults With Mild Cognitive Impairment or Remitted Major Depressive Disorder: An Analysis of the PACt-MD Randomized Clinical Trial.

Biological psychiatry·2026
Same journal

Remembering Jon-Kar Zubieta, M.D., Ph.D.

Biological psychiatry·2026
Same journal

Kappa opioid receptor availability in borderline personality disorder: An in-vivo investigation with [<sup>11</sup>C]EKAP PET imaging.

Biological psychiatry·2026
Same journal

From Satiety to Substance Use: Neural Mechanisms of GLP-1 Signaling in Appetite and Reward.

Biological psychiatry·2026
Same journal

Distinct and Shared Molecular Mechanisms Underlie Morphological-Functional Overcoupling and Undercoupling in Major Depressive Disorder.

Biological psychiatry·2026
Same journal

Dynamic Brain States With Cannabis Intoxication: Beyond "More Is Better" in Interpreting Brain Connectivity.

Biological psychiatry·2026
See all related articles

Related Experiment Video

Updated: May 9, 2026

Paradigms for Behavioral Assessment in Drosophila Model of Autism Spectrum Disorder
08:30

Paradigms for Behavioral Assessment in Drosophila Model of Autism Spectrum Disorder

Published on: September 6, 2024

Risk for Autism Across Generations.

Abraham Reichenberg1, Diana Schendel2, Mika Gissler3

  • 1Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, New York; Department of Environmental Medicine, Icahn School of Medicine at Mount Sinai, New York, New York; Seaver Autism Center for Research and Treatment at Mount Sinai, New York, New York; Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, New York.

Biological Psychiatry
|May 7, 2026
PubMed
Summary
This summary is machine-generated.

Paternal age at daughter's birth increases autism risk in grandchildren, while young maternal age is linked to autism risk across generations. These findings suggest multi-generational inheritance patterns for autism spectrum disorder (ASD).

Keywords:
AutismEpidemiologyMaternal ageMultigenerationPaternal ageRisk factors

More Related Videos

Dynamic Clamp Methods to Investigate Impaired Neuronal Excitability Associated with Autism
08:44

Dynamic Clamp Methods to Investigate Impaired Neuronal Excitability Associated with Autism

Published on: October 17, 2025

A Strategy to Identify de Novo Mutations in Common Disorders such as Autism and Schizophrenia
05:51

A Strategy to Identify de Novo Mutations in Common Disorders such as Autism and Schizophrenia

Published on: June 15, 2011

Related Experiment Videos

Last Updated: May 9, 2026

Paradigms for Behavioral Assessment in Drosophila Model of Autism Spectrum Disorder
08:30

Paradigms for Behavioral Assessment in Drosophila Model of Autism Spectrum Disorder

Published on: September 6, 2024

Dynamic Clamp Methods to Investigate Impaired Neuronal Excitability Associated with Autism
08:44

Dynamic Clamp Methods to Investigate Impaired Neuronal Excitability Associated with Autism

Published on: October 17, 2025

A Strategy to Identify de Novo Mutations in Common Disorders such as Autism and Schizophrenia
05:51

A Strategy to Identify de Novo Mutations in Common Disorders such as Autism and Schizophrenia

Published on: June 15, 2011

Area of Science:

  • Genetics and Genomics
  • Developmental Neuroscience
  • Public Health

Background:

  • Autism spectrum disorder (ASD) exhibits complex inheritance, with a male predominance.
  • Etiological models implicate common and rare genetic variations in ASD risk.
  • A hypothesis suggests inherited rare variations contribute to risk across generations, particularly via female lineage.

Purpose of the Study:

  • To investigate the multi-generational transmission of autism spectrum disorder (ASD) risk.
  • To examine the role of parental age across generations in relation to ASD diagnosis in offspring.
  • To test the hypothesis of inherited risk factors, especially through female lineage.

Main Methods:

  • Analysis of combined national register data from Sweden, Denmark, and Finland (12.6 million individuals).
  • Inclusion of parental age information across two generations.
  • Assessment of autism spectrum disorder (ASD) diagnosis in the third generation.

Main Results:

  • Increased paternal age at daughter's birth correlated with higher ASD risk in the next generation.
  • No association found between increased paternal age at son's birth and ASD risk in offspring.
  • Young maternal age at birth was associated with increased ASD risk in offspring.

Conclusions:

  • Etiological risk factors for ASD may span multiple generations.
  • Findings suggest distinct genetic and non-genetic mechanisms underlying multi-generational ASD risk.
  • Further research into trans-generational risk factors for autism is warranted.