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Antigen mapping in hereditary epidermolysis bullosa

C R Srinivas1, A Sandra, S D Shenoi

  • 1From the Department of Skin and STD, Kasturba Hospital, Manipal-576119, India and from the Department of Immuno Dermatology, St. Thomas Hospital, London, United Kingdom.

Indian Journal of Dermatology, Venereology and Leprology
|October 6, 2010
PubMed

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The term desmosome derives from the Greek words "desmo" and "soma" meaning "adhesion bodies." This structure was first observed during the late 1800s and described as small, dense nodules in the epidermis. Desmosomes are button-like structures that help form an interlinked network of intermediate filaments across the cells. These junctions are  essential to hold cells together under mechanical stress and to maintain tissue integrity. Desmosomes are multi-protein complexes comprising desmosomal...