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Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty
10:03

Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty

Published on: January 28, 2020

Predictive value of the relative lymphocyte count in coronary heart disease

Chang Bian1, Yihua Wu, Yu Shi

  • 1Department of Cardiology, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310009, People's Republic of China.

Heart and Vessels
|October 6, 2010
PubMed

Insights

A decreased percentage of lymphocytes (L%) may indicate physiological stress in coronary heart disease (CHD) patients. This study found low L% is an independent predictor for acute coronary syndrome (ACS) and major adverse cardiac events (MACE) in CHD.

Area of Science:

  • Cardiology
  • Hematology
  • Clinical Medicine

Background:

  • Physiological stress in coronary heart disease (CHD) can alter leukocyte differential counts.
  • A decreased percentage of lymphocytes (L%) is a potential indicator of this stress.

Purpose of the Study:

  • To investigate the prognostic significance of a low L% in patients with CHD.
  • To determine if low L% predicts adverse cardiac events.

Main Methods:

  • Retrospective review of 140 CHD patients (2007-2008).
  • Analysis included patients undergoing primary or elective percutaneous coronary intervention (PCI).
  • Statistical analyses (univariate, multivariate, logistic regression) examined associations between L%, clinical characteristics, and outcomes.

Main Results:

  • Low L% was significantly associated with acute coronary syndrome (ACS) compared to stable CHD.
  • White blood cell (WBC) count, C-reactive protein (CRP), and left ventricular systolic dysfunction (LVSD) also correlated with CHD.
  • L%, CRP, WBC count, and LVSD were independent predictors of CHD and 1-year major adverse cardiac events (MACE).

Conclusions:

  • A low L% serves as an independent predictor for ACS upon admission in CHD patients.
  • Low L% is associated with MACE during clinical follow-up for CHD patients.
  • L% offers prognostic value in managing CHD patients.

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