A review of probabilistic analysis in orthopaedic biomechanics

Probabilistic analysis methods are being increasingly applied in the orthopaedics and biomechanics literature to account for uncertainty and variability in subject geometries, properties of various structures, kinematics and joint loading, as well as uncertainty in implant alignment. As a complement to experiments, finite element modelling, and statistical analysis, probabilistic analysis provides a method of characterizing the potential impact of variability in parameters on performance. This paper presents an overview of probabilistic analysis and a review of biomechanics literature utilizing probabilistic methods in structural reliability, kinematics, joint mechanics, musculoskeletal modelling, and patient-specific representations. The aim of this review paper is to demonstrate the wide range of applications of probabilistic methods and to aid researchers and clinicians in better understanding probabilistic analyses.