Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Inflammatory Response01:28

Inflammatory Response

An inflammatory response is a localized, nonspecific immune reaction that occurs when a tissue is injured. It is characterized by redness, swelling, heat, and pain, which are commonly called the cardinal signs and symptoms of inflammation. Inflammation can sometimes result in a loss of function.
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
T Cell Types and Functions01:24

T Cell Types and Functions

When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
Lipid-derived Compounds in the Human Body01:31

Lipid-derived Compounds in the Human Body

Fats and lipids are crucial components in the human body. Some lipid-derived compounds, such as fat-soluble vitamins, eicosanoids, lipoproteins, and glycolipids, also play unique roles to support various  biological processes .
Fat-soluble Vitamins
Fat-soluble vitamins, including vitamins A, D, E, and K, are required in minimal quantities, but their deficiencies can lead to severely abnormal physiological conditions. For example, vitamin A deficiency can cause night blindness, dry skin, delayed...
Inflammation01:38

Inflammation

Overview
Inflammatory Response II: Inflammatory Exudate and Tissue Repair01:24

Inflammatory Response II: Inflammatory Exudate and Tissue Repair

The immune system's inflammatory response destroys the invading pathogen, permitting the tissue to heal. The changes during the cellular and vascular stages allow exudate formation at the site of inflammation. The inflammatory exudate released from the wound has high protein content and a specific gravity above 1.020.
The typical wound exudate is odorless, transparent, straw-colored, thin, and watery. Exudate, however, can differ depending on the state of wound healing. Likewise, the exudate's...
Inflammatory Response I: Vascular and Cellular01:30

Inflammatory Response I: Vascular and Cellular

The inflammatory response is the body's defense against infection, injury, or irritation from bacteria, trauma, toxins, or heat. Inflammation helps locate and destroy pathogens and remove damaged tissue elements to heal the body. During this initial phase, fluid, blood products, and nutrients migrate to the injured area, resulting in redness, heat, swelling, ache, and loss of function. Moreover, signs of systemic inflammation include fever, increased WBC count, malaise, anorexia, nausea,...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Depletion of eosinophils during sensitization but not challenge phase in mice blocks the development of food allergy early in life.

Journal of immunology (Baltimore, Md. : 1950)·2025
Same author

Maternal supplementation with α-tocopherol inhibits the development of offspring food allergy, H1R signaling and ultimately anaphylaxis early in life.

Journal of immunology (Baltimore, Md. : 1950)·2025
Same author

Dendritic cell-specific deletion of PKCδ in offspring of allergic mothers prevents the predisposition for development of allergic lung inflammation in offspring.

Journal of leukocyte biology·2024
Same author

Increased vascular deposition of oxidized LDL in untreated juvenile dermatomyositis.

Pediatric rheumatology online journal·2024
Same author

Viral Vector Based Immunotherapy for Peanut Allergy.

Viruses·2024
Same author

Mechanisms for initiation of food allergy by skin pre-disposed to atopic dermatitis.

Immunological reviews·2024
Same journal

Expression of IL-35 in the Prophase of Liver Failure and its Immune Regulatory Interaction with Glucocorticoids.

Endocrine, metabolic & immune disorders drug targets·2026
Same journal

Celastrol Attenuates Fgf23 Expression in Osteoblasts by Inhibiting STAT3 Activation.

Endocrine, metabolic & immune disorders drug targets·2026
Same journal

Mendelian Randomization Analysis of the Inflammatory Factor CXCL5 and Type 2 Diabetes Mellitus.

Endocrine, metabolic & immune disorders drug targets·2026
Same journal

Clinical Exome Sequencing Study in a Cohort of Growth Hormone-Secreting Pituitary Adenomas.

Endocrine, metabolic & immune disorders drug targets·2026
Same journal

A Review of the Mechanisms, Biological Basis, and Active Ingredients of Traditional Chinese Medicine Formulations in Regulating Organ Function to Alleviate Osteoporosis.

Endocrine, metabolic & immune disorders drug targets·2026
Same journal

Potential of IL-33 as a Novel Myokine in Sarcopenia-Osteoporosis Communication: Insights from Mendelian Randomization.

Endocrine, metabolic & immune disorders drug targets·2026
See all related articles

Related Experiment Video

Updated: Jun 8, 2026

Screening Assays to Characterize Novel Endothelial Regulators Involved in the Inflammatory Response
12:50

Screening Assays to Characterize Novel Endothelial Regulators Involved in the Inflammatory Response

Published on: September 15, 2017

Isoforms of vitamin E differentially regulate inflammation.

Joan M Cook-Mills1, Christine A McCary

  • 1Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA. j-cook-mills@northwestern.edu

Endocrine, Metabolic & Immune Disorders Drug Targets
|October 7, 2010
PubMed
Summary
This summary is machine-generated.

Vitamin E isoforms have opposing regulatory functions in inflammation, challenging previous research. Understanding these distinct roles is crucial for reinterpreting vitamin E

More Related Videos

A Method of Trigonometric Modelling of Seasonal Variation Demonstrated with Multiple Sclerosis Relapse Data
10:46

A Method of Trigonometric Modelling of Seasonal Variation Demonstrated with Multiple Sclerosis Relapse Data

Published on: December 9, 2015

Related Experiment Videos

Last Updated: Jun 8, 2026

Screening Assays to Characterize Novel Endothelial Regulators Involved in the Inflammatory Response
12:50

Screening Assays to Characterize Novel Endothelial Regulators Involved in the Inflammatory Response

Published on: September 15, 2017

A Method of Trigonometric Modelling of Seasonal Variation Demonstrated with Multiple Sclerosis Relapse Data
10:46

A Method of Trigonometric Modelling of Seasonal Variation Demonstrated with Multiple Sclerosis Relapse Data

Published on: December 9, 2015

Area of Science:

  • Immunology
  • Nutritional Science
  • Biochemistry

Background:

  • Vitamin E's role in disease regulation is widely studied, often focusing on alpha-tocopherol.
  • Clinical studies on alpha-tocopherol's anti-inflammatory effects in conditions like asthma and atherosclerosis yield contradictory results.

Purpose of the Study:

  • To review the regulatory functions of vitamin E isoforms in inflammation.
  • To provide alternative interpretations of previous vitamin E studies based on isoform-specific activities.

Main Methods:

  • Literature review of human, animal, and cell system studies on vitamin E and inflammation.
  • Analysis of recent findings on the opposing regulatory functions of natural vitamin E isoforms.

Main Results:

  • Physiological levels of different vitamin E isoforms exhibit opposing regulatory functions during inflammation.
  • The immunoregulatory effects of vitamin E isoforms are not fully reversible by other isoforms.

Conclusions:

  • Previous studies on vitamin E and inflammation may require reinterpretation due to unrecognized isoform-specific properties.
  • The complex interplay of vitamin E isoforms significantly impacts their overall regulatory role in inflammatory processes.