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Updated: Jun 8, 2026

Improved Home Blood Pressure Control by CT-guided Ozone-mediated Renal Denervation for Patients with Resistant Hypertension

Improved Home Blood Pressure Control by CT-guided Ozone-mediated Renal Denervation for Patients with Resistant Hypertension

Published on: June 6, 2025

Catheter-based renal sympathectomy.

D Id¹, S C Bertog, N Wunderlich

¹Cardiovascular Center Frankfurt, St.Katharinen Hospital, Frankfurt, Germany.

The Journal of Cardiovascular Surgery

|October 7, 2010

Summary

This summary is machine-generated.

The sympathetic nervous system and kidneys play crucial roles in blood pressure regulation and hypertension. Renal denervation offers a potential therapeutic target for resistant hypertension by modulating sympathetic activity.

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Improved Home Blood Pressure Control by CT-guided Ozone-mediated Renal Denervation for Patients with Resistant Hypertension

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Published on: January 10, 2019

Area of Science:

Nephrology
Cardiovascular Physiology
Hypertension Research

Background:

The sympathetic nervous system (SNS) significantly influences blood pressure regulation and hypertension pathogenesis through its effects on the kidneys.
The kidney's dense sympathetic innervation allows it to modulate sympathetic tone, making it both a contributor and a target in sympathetic overactivity.
Conditions like heart failure, chronic kidney disease, and metabolic syndrome are linked to elevated sympathetic activity, irrespective of hypertension status.

Purpose of the Study:

To review the role of the SNS in blood pressure control and hypertension.
To discuss the kidney as a therapeutic target for managing hypertension and conditions with high sympathetic tone.
To evaluate the efficacy and indications for selective renal sympathectomy, particularly in treatment-resistant hypertension.

Main Methods:

Review of existing literature on the sympathetic nervous system, kidney function, and hypertension.
Exploration of historical and current therapeutic interventions targeting renal sympathetic nerves.
Analysis of the role of elevated sympathetic tone in resistant hypertension.

Main Results:

The kidney is integral to blood pressure regulation and hypertension development via sympathetic pathways.
Therapeutic strategies have evolved from extensive sympathectomy to minimally invasive renal denervation.
Selective renal sympathectomy may benefit a subset of hypertensive patients with treatment resistance due to elevated sympathetic tone.

Conclusions:

The interplay between the SNS and kidneys is critical in cardiovascular homeostasis and disease.
Minimally invasive renal denervation represents a targeted approach for managing resistant hypertension.
Further research into renal denervation's role in specific patient populations is warranted.