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Updated: Jun 8, 2026
07:59
Translationally-Relevant Tumor Resection Model for Murine Preclinical Models of Oral Squamous Cell Carcinoma
Published on: April 3, 2026
Angiosarcoma of the oral cavity
1Department of Pathology, Shizuoka City Shimizu Hospital, Shimizu-Ku, Shizuoka, Japan. piyo0111jp@yahoo.co.jp
Head and Neck Pathology
|October 7, 2010
Summary
A rare oral cavity angiosarcoma in a 54-year-old woman presented as a cheek mass. Diagnosis was confirmed via immunohistochemistry, revealing a highly aggressive tumor requiring further treatment.
Area of Science:
- Oncology
- Pathology
- Surgical Oncology
Background:
- Angiosarcoma of the oral cavity is an exceptionally rare malignancy.
- Early detection and accurate diagnosis are crucial for effective management.
Observation:
- A 54-year-old female presented with a 1 cm left cheek mass near the mandible.
- MRI revealed a non-encapsulated tumor with a central cavity.
- Histological examination showed spindle and polygonal cells with hyperchromatic nuclei, mitotic figures, and vasoformative channels.
Findings:
- Immunohistochemistry confirmed angiosarcoma, with positive markers for factor VIII-related antigen, CD31, CD34, vimentin, and p53 protein.
- The tumor exhibited invasiveness, lymphovascular permeation, and positive surgical margins.
- High Ki-67 labeling (46%) indicated significant proliferative activity.
Implications:
- This case highlights the diagnostic challenges of rare oral angiosarcomas.
- Aggressive features necessitate comprehensive treatment strategies, including radical surgery.
- Further research into optimal management protocols for oral angiosarcoma is warranted.
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