Related Experiment Video
Updated: Jun 8, 2026

Synthesis of pH Dependent Pyrazole, Imidazole, and Isoindolone Dipyrrinone Fluorophores using a Claisen-Schmidt Condensation Approach
Published on: June 10, 2021
Novel chalcones and 1,3,5-triphenyl-2-pyrazoline derivatives as antibacterial agents
Ponnurengam Malliappan Sivakumar1, Suresh Ganesan, Prabhawathi Veluchamy
1Department of Biotechnology, Indian Institute of Technology Madras, Adyar, Chennai, India.
Abstract:
Novel sixteen chalcones and thirteen 1,3,5-triphenyl-2-pyrazolines were synthesized and characterized using FT-IR, HR-Mass, NMR (¹H-NMR, ¹³C-NMR, 135 DEPT, ¹H-¹H CoSY and ¹H and ¹³C CoSY) and XRD. These compounds were evaluated for their antibacterial activity against six micro-organisms, namely Bacillus subtilis NCIM 2718, Staphylococcus aureus NCIM 5021, Salmonella typhi NCIM 2501, Enterobacter aerogenes NCIM 5139, Pseudomonas aeruginosa NCIM 5029, and Proteus vulgaris NCIM 2813 by twofold dilution method using resazurin as the indicator dye. In the case of chalcones, compounds with hydroxyl and bromo substitutions in the B-ring favor activity and benzyloxy substitution irrespective of its position in the A-ring. In the case of 1,3,5-triphenyl-2-pyrazolines, chloro substitution in the A-ring favors activity. Hydrophilic/lipophilic balance of the compounds plays a major role in their antibacterial activity.
Related Concept Videos
Inhibitors of Bacterial DNA Synthesis
Bacterial Phylum Chlamydiae
Aryldiazonium Salts to Azo Dyes: Diazo Coupling
Cholinergic Antagonists: Chemistry and Structure-Activity Relationship
Cholinergic Antagonists: Pharmacokinetics
Inhibitors of Gram-positive Cell Wall Synthesis

