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Continuous Manual Exchange Transfusion for Patients with Sickle Cell Disease: An Efficient Method to Avoid Iron Overload

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[First French transfusions (1667-1668)].

P Jaulin¹, J-J Lefrère

¹Institut national de la transfusion sanguine, 6, rue Alexandre-Cabanel, 75015 Paris, France.

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|October 8, 2010

Summary

Early blood transfusions in the 17th century, primarily in France and England, involved animal experimentation and human attempts. These early procedures lacked immunological understanding, leading to a fatal incident and a subsequent ban on transfusions.

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Area of Science:

Medical History
Immunology
Transfusion Medicine

Background:

The 17th century marked the genesis of blood transfusion attempts.
Pioneering efforts occurred in France and England, involving animal experimentation and human trials.
Early transfusions disregarded critical immunological dangers.

Observation:

Early transfusion pioneers included Dom Robert and Jean-Baptiste Denis in France.
Transfusions were performed without understanding immunological risks.
A patient death, likely due to acute intravascular hemolysis, was recorded.

Findings:

The first recorded human transfusions occurred in the 17th century.
Lack of immunological knowledge was a significant factor in early transfusion outcomes.
A fatal outcome linked to hemolysis led to the prohibition of transfusions.

Implications:

The initial phase of transfusion medicine was halted due to safety concerns.
This historical event underscores the importance of immunological compatibility in transfusions.
Early failures paved the way for future research into safe transfusion practices.