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Updated: Jun 8, 2026

Detection of Copy Number Alterations Using Single Cell Sequencing
Published on: February 17, 2017
CopyMap: localization and calling of copy number variation by joint analysis of hybridization data from multiple
1Department of Biostatistics, University of Michigan, 1420 Washington Heights, Ann Arbor, MI 48109, USA. szoellne@umich.edu
Summary:
The program package CopyMap identifies copy number variation from oligo-hybridization and CGH data. Using a time-dependent hidden Markov model to combine evidence of copy number variants (CNVs) across multiple carriers, CopyMap is substantially more accurate than standard hidden Markov methods in identifying CNVs and calling CNV-carriers. Moreover, CopyMap provides more precise estimates of CNV-boundaries.
Availability:
The C-source code and detailed documentation for the program CopyMap is available on the Internet at http://www.sph.umich.edu/csg/szoellner/
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