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Induction of Murine Intestinal Inflammation by Adoptive Transfer of Effector CD4+CD45RBhigh T Cells into Immunodeficient Mice
Published on: April 21, 2015
Vaccines and inflammatory bowel disease.
1Transplant Infectious Disease and Compromised Host Program, Division of Infectious Diseases, Massachusetts General Hospital, and Department of Medicine, Harvard Medical School, Boston, MA, USA. ckotton@partners.org
Patients with inflammatory bowel disease (IBD) face higher infection risks. Routine vaccination is recommended, even if immunity is reduced, to offer protection, especially during less intensive immunosuppressive therapy.
Area of Science:
- Gastroenterology and Immunology
- Infectious Disease Prevention
Background:
- Patients with inflammatory bowel disease (IBD), encompassing Crohn's disease and ulcerative colitis, exhibit heightened susceptibility to infections.
- This increased vulnerability stems from both the autoimmune nature of IBD and the immunosuppressive treatments employed for disease management.
- Despite recommendations for routine vaccination, significant opportunities to immunize this high-risk group are frequently missed.
Purpose of the Study:
- To underscore the critical need for routine vaccination in patients diagnosed with inflammatory bowel disease.
- To highlight the challenges and missed opportunities in vaccinating this vulnerable patient cohort.
- To provide guidance on vaccine administration in IBD patients, considering disease activity and immunosuppression levels.
Main Methods:
- Review of existing literature and guidelines on vaccination in IBD patients.
- Analysis of factors influencing vaccine immunogenicity and efficacy in immunosuppressed individuals.
- Discussion of specific vaccine recommendations, including live viral vaccines, based on immunosuppression intensity.
Main Results:
- Vaccination in IBD patients, while potentially yielding attenuated immunogenicity, is likely to provide some degree of protection.
- Optimal vaccination timing involves periods of reduced immunosuppressive therapy to enhance immune response.
- Live viral vaccines necessitate careful consideration and avoidance during intense immunosuppression phases.
Conclusions:
- Routine vaccination is a crucial, yet often overlooked, preventive strategy for IBD patients.
- Vaccination timing relative to immunosuppression levels significantly impacts efficacy.
- Adherence to specific vaccine guidelines is essential for maximizing protection and minimizing risks in IBD management.
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